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Histogram showing the effect of dopamine D1 or D2 receptor antagonists on METH-induced trafficking of the neurokinin-1 receptors of the striatum. Treatment groups and conditions were as in Figure 5 above. Note that both SCH-23390 (D1 antagonist) and raclopride (D2 antagonist) were effective in preventing trafficking of the neurokinin-1 receptors in the presence of METH. V, vehicle; R, raclopride; S, saline; SCH, SCH-23390; M, METH; NK1R, neurokinin-1 receptor. !p<0.0001; *p<0.01.
