Figure 6.

Estimation of a broad step-size distribution as in Fig. 5, but from a 40,000-point time course containing 4000 steps. (A) Simulated step-size distribution. (B) Convergence of L with a 1-state HMM when the simulated time-course had 3, 7, 10, or 15 nm RMS of added Gaussian noise. (C–F) Estimated step-size distributions from data having the indicated noise standard deviations σ. The final estimated step-size distributions c(w) (solid lines) and the distributions obtained after partial convergence, when L was 1 log-unit below its final value (solid bars), are plotted. Note that the continuous distribution in panel A is better recovered with this larger dataset as compared with Fig. 5.