Table 1. Previously unrecognized ORFs conserved in the four clinical isolates.
ORF | Position | Strand | AD169 | Towne | ChCMV |
---|---|---|---|---|---|
C-ORF1 | 1911-2219 | + | + | + | - |
C-ORF2 | 2002-2313 | - | + | + | + |
C-ORF3 | 3201-3464 | - | - | + | - |
C-ORF4 | 7721-7993 | + | + | + | - |
C-ORF5 | 8623-8946 | - | + | + | - |
C-ORF6 | 23457-23714 | - | + | + | - |
C-ORF7 | 29049-29441 | + | + | + | + |
C-ORF8 | 34809-35084 | + | + | + | - |
C-ORF9 | 35428-35847 | - | + | + | + |
C-ORF10 | 42908-43321 | + | + | + | + |
C-ORF11 | 46173-46517 | - | + | + | - |
C-ORF12 | 53739-54098 | - | + | - | - |
C-ORF13 | 54532-54792 | + | + | + | + |
C-ORF14 | 54705-55322 | + | + | + | + |
C-ORF15 | 120245-120505 | - | + | + | + |
C-ORF16 | 157089-157358 | - | + | + | - |
C-ORF17 | 159004-159321 | + | + | + | - |
C-ORF18 | 161498-161749 | - | + | + | + |
C-ORF19 | 162157-162567 | - | + | + | - |
C-ORF20 | 166218-166598 | + | + | + | - |
C-ORF21 | 167837-168241 | + | + | + | + |
C-ORF22 | 168302-168568 | + | + | + | + |
C-ORF23 | 175896-176174 | + | + | + | + |
C-ORF24 | 184793-185437 | + | - | - | + |
C-ORF25 | 190194-190643 | - | - | - | - |
C-ORF26 | 190299-190754 | + | - | - | - |
C-ORF27 | 204440-204773 | + | + | + | - |
C-ORF28 | 205251-205532 | + | + | + | + |
C-ORF29 | 207279-207572 | - | + | + | + |
The ORFs are positioned in the FIX sequence, which has been organized into the order of the conventional map for clinical isolates that is displayed in Fig. 1A. blastp was used to search for homologues to the conserved ORFs in the AD169 and Towne sequences reported here, as well as in the chimpanzee cytomegalovirus (ChCMV) sequence (4).