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. 2010 Nov;161(5):1111–1121. doi: 10.1111/j.1476-5381.2010.00953.x

Figure 2.

Figure 2

Nrf2 disruption led to decreased antioxidant protein activities upon LCA challenge in mice. Total hepatic GSH levels (lower panel), Trx (middle panel) and GST (upper panel) activities of mice treated with vehicle or LCA (125 mg·kg−1 body wt. twice daily for 4 days). Mean ± SEM: n = 6–8. **P < 0.01 from Nrf2+/+ mice within vehicle or LCA treatment group; #P < 0.01 from Nrf2+/+ mice administered vehicle control; n = 6–8. GSH, glutathione; GST, glutathione S-transferase; LCA, lithocholic acid; Nrf2, nuclear factor (erythroid 2-related) factor 2; Trx1, thioredoxin reductase 1.