Table 3.
Individual profiles of BCP/PC mutations in patients infected with genotypes B and C
| HB-ACLF (n = 75) | CHB (n = 328) | P value | |
|---|---|---|---|
| Genotype B (n = 77) | |||
| Patient number | 23 | 54 | |
| Wild type | 0 | 21 | <0.001 |
| T1753V | 2 (8.7%) | 2 (3.7%) | 0.366 |
| T1754G | 2 (8.7%) | 3 (5.6%) | 0.714 |
| A1762T | 14 (60.9%) | 15 (27.8%) | 0.006 |
| G1764A | 14 (60.9%) | 15 (27.8%) | 0.006 |
| C1766T | 0 | 0 | – |
| T1768A | 0 | 0 | – |
| G1896A | 13 (56.5%) | 23 (42.6%) | 0.262 |
| G1899A | 3 (13.0%) | 4 (7.4%) | 0.431 |
| Substitution/sample* | 2.17 | 1.19 | <0.001 |
| Genotype C (n = 323) | |||
| Patient number | 52 | 271 | |
| Wild type | 0 | 68 | <0.001 |
| T1753C/A/G | 19 (36.5%) | 49 (18.1%) | <0.001 |
| T1754C/G | 1 (1.9%) | 5 (1.8%) | 0.654 |
| A1762T | 44 (84.6%) | 157 (57.9%) | <0.001 |
| G1764A | 48 (92.3%) | 162 (59.8%) | <0.001 |
| C1766T | 5 (9.6%) | 16 (5.9%) | 0.320 |
| T1768A | 2 (3.8%) | 8 (3.0%) | 0.733 |
| G1896A | 20 (38.5%) | 82 (30.3%) | 0.049 |
| G1899A | 9 (17.3%) | 18 (6.6%) | 0.002 |
| Substitution/sample* | 2.92 | 1.88 | <0.001 |
HB-ACLF, hepatitis B-related acute-on-chronic liver failure; BCP, basal core promoter; CHB, chronic hepatitis B; PC, precore.
*
Represents the average number of substitutions at the eight analyzed sites from the BCP/PC regions.