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. 2010 Dec;17(12):887–895. doi: 10.1111/j.1365-2893.2009.01254.x

Table 3.

Individual profiles of BCP/PC mutations in patients infected with genotypes B and C

HB-ACLF (n = 75) CHB (n = 328) P value
Genotype B (n = 77)
Patient number 23 54
Wild type 0 21 <0.001
T1753V 2 (8.7%) 2 (3.7%) 0.366
T1754G 2 (8.7%) 3 (5.6%) 0.714
A1762T 14 (60.9%) 15 (27.8%) 0.006
G1764A 14 (60.9%) 15 (27.8%) 0.006
C1766T 0 0
T1768A 0 0
G1896A 13 (56.5%) 23 (42.6%) 0.262
G1899A 3 (13.0%) 4 (7.4%) 0.431
Substitution/sample* 2.17 1.19 <0.001
Genotype C (n = 323)
Patient number 52 271
Wild type 0 68 <0.001
T1753C/A/G 19 (36.5%) 49 (18.1%) <0.001
T1754C/G 1 (1.9%) 5 (1.8%) 0.654
A1762T 44 (84.6%) 157 (57.9%) <0.001
G1764A 48 (92.3%) 162 (59.8%) <0.001
C1766T 5 (9.6%) 16 (5.9%) 0.320
T1768A 2 (3.8%) 8 (3.0%) 0.733
G1896A 20 (38.5%) 82 (30.3%) 0.049
G1899A 9 (17.3%) 18 (6.6%) 0.002
Substitution/sample* 2.92 1.88 <0.001

HB-ACLF, hepatitis B-related acute-on-chronic liver failure; BCP, basal core promoter; CHB, chronic hepatitis B; PC, precore.

*

Represents the average number of substitutions at the eight analyzed sites from the BCP/PC regions.