Table 4.
HBV BCP/PC patterns distributed in the two groups of patients
| HB-ACLF | CHB | P value | |
|---|---|---|---|
| Basic BCP/PC mutations* | n = 75 | n = 328 | |
| −/− | 5 (6.7%) | 119 (36.2%) | <0.001 |
| +/− | 37 (49.3%) | 104 (31.7%) | 0.003 |
| −/+ | 12 (16.0%) | 41 (12.5%) | 0.262 |
| +/+ | 21 (28.0%) | 64 (19.5%) | 0.073 |
| ±/+ | 33 (44.0%) | 105 (32.0%) | 0.034 |
| Triple BCP mutations† | n = 52 | n = 271 | |
| T1753V/A1762T/G1764A | 19 (36.5%) | 48 (17.7%) | 0.002 |
| A1762T/G1764A/C1766T (or T1768A) | 6 (11.5%) | 11 (4.1%) | 0.027 |
HB-ACLF, hepatitis B-related acute-on-chronic liver failure; BCP, basal core promoter; CHB, chronic hepatitis B; HBV, hepatitis B virus; PC, precore.
*
Positivity (+) or negativity (−) of basic BCP and PC mutations was based on the presence or absence of A1762T/G1764A and G1896A, respectively.
†
Only genotype C HBV-infected patients were analyzed. A1762T/G1764A/C1766T (or T1768A) may be concomitant with T1753V.