Table 5.
The clinical and viral characteristics in relation to mortality in patients with hepatitis B-related acute-on-chronic liver failure
| Factors | Survival | Nonsurvival | P value | Odds ratio |
|---|---|---|---|---|
| Basic BCP/PC mutations | ||||
| −/− | 2 | 3 | – | |
| +/− | 21 | 16 | 0.028 | 0.35 (0.14–0.90) |
| ±/+ | 10 | 23 | 0.026 | 3.02 (1.1–8.10) |
| HBeAg | ||||
| + | 15 | 23 | 0.424 | 1.45 (0.58–3.63) |
| − | 18 | 19 | 1 | |
| Total bilirubin | ||||
| <450 μmol/L | 21 | 15 | 0.016 | 1 |
| ≥450 μmol/L | 12 | 27 | 3.15 (1.22–8.14) | |
| Prothrombin activity (%) | ||||
| <23 | 11 | 27 | 0.007 | 3.60 (1.38–9.41) |
| ≥23 | 22 | 15 | 1 | |
| HBV DNA | ||||
| <105 copies/mL | 11 | 6 | 0.050 | 1 |
| ≥105 copies/mL | 22 | 36 | 3.00 (0.97–9.26) | |
| Genotype | ||||
| B | 7 | 16 | 0.092 | 2.29 (0.81–6.48) |
| C | 26 | 26 | 1 | |
| Age | ||||
| <40 years | 19 | 18 | 0.151 | 1 |
| ≥40 years | 14 | 24 | 1.81 (0.72–4.55) | |
BCP, basal core promoter; HBV, hepatitis B virus; PC, precore.