Table 1.
Genome-wide Association Results for Systolic Blood Pressure SNPs with P Value <1×10-6 Sorted by Systolic Blood Pressure Meta-analysis P Value
| SNP identifier | Chr | Position | Gene | MAF | CHARGE Meta-analysis SBP | CHARGE Meta-analysis DBP | CHARGE Meta-analysis Hypertension | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Beta | SE | p | Beta | SE | p | Beta | SE | p | |||||
| rs2681492 | 12 | 88537220 | ATP2B1 | 0.20 | -1.26 | 0.19 | 3.0E-11 | -0.62 | 0.11 | 4.6E-08 | -0.14 | 0.03 | 8.4E-08 |
| rs2681472 | 12 | 88533090 | ATP2B1 | 0.18 | -1.29 | 0.19 | 3.5E-11 | -0.64 | 0.11 | 3.7E-08 | -0.16 | 0.03 | 1.7E-08 |
| rs11105354 | 12 | 88550654 | ATP2B1 | 0.18 | -1.30 | 0.20 | 3.7E-11 | -0.63 | 0.11 | 5.8E-08 | -0.16 | 0.03 | 1.8E-08 |
| rs11105364 | 12 | 88593407 | 0.18 | -1.30 | 0.20 | 4.8E-11 | -0.63 | 0.12 | 1.2E-07 | -0.16 | 0.03 | 2.1E-08 | |
| rs17249754 | 12 | 88584717 | 0.18 | -1.30 | 0.20 | 5.2E-11 | -0.63 | 0.12 | 1.0E-07 | -0.16 | 0.03 | 2.2E-08 | |
| rs11105368 | 12 | 88598572 | 0.18 | -1.30 | 0.20 | 5.3E-11 | -0.63 | 0.12 | 1.3E-07 | -0.16 | 0.03 | 2.2E-08 | |
| rs12579302 | 12 | 88574634 | 0.18 | -1.29 | 0.20 | 6.2E-11 | -0.62 | 0.12 | 1.3E-07 | -0.16 | 0.03 | 2.2E-08 | |
| rs12230074 | 12 | 88614998 | 0.17 | -1.31 | 0.20 | 9.1E-11 | -0.62 | 0.12 | 3.4E-07 | -0.17 | 0.03 | 2.9E-08 | |
| rs11105378 | 12 | 88614872 | 0.17 | -1.31 | 0.20 | 9.1E-11 | -0.62 | 0.12 | 3.1E-07 | -0.17 | 0.03 | 2.8E-08 | |
| rs4842666 | 12 | 88465680 | 0.17 | -1.20 | 0.21 | 6.5E-09 | -0.62 | 0.12 | 4.5E-07 | -0.15 | 0.03 | 3.4E-07 | |
| rs8096897 | 18 | 13428905 | C18orf1 | 0.01 | -12.87 | 2.33 | 3.2E-08 | -4.07 | 1.33 | 2.9E-03 | -0.73 | 0.35 | 0.04 |
| rs11105328 | 12 | 88466521 | 0.18 | -1.11 | 0.20 | 4.2E-08 | -0.61 | 0.12 | 5.1E-07 | -0.15 | 0.03 | 7.1E-07 | |
| rs880315 | 1 | 10719453 | CASZ1 | 0.35 | 0.89 | 0.17 | 2.1E-07 | 0.30 | 0.10 | 2.9E-03 | 0.09 | 0.02 | 6.2E-05 |
| rs3184504 | 12 | 110368991 | SH2B3 | 0.48 | 0.75 | 0.15 | 5.7E-07 | 0.50 | 0.09 | 1.7E-08 | 0.07 | 0.02 | 7.4E-04 |
| rs381815 | 11 | 16858844 | PLEKHA7 | 0.26 | 0.84 | 0.17 | 5.8E-07 | 0.51 | 0.10 | 4.3E-07 | 0.09 | 0.02 | 1.7E-04 |
| rs7926335 | 11 | 16874445 | PLEKHA7 | 0.26 | 0.85 | 0.17 | 5.8E-07 | 0.51 | 0.10 | 4.8E-07 | 0.09 | 0.02 | 1.9E-04 |
| rs7571613 | 2 | 190513907 | PMS1 | 0.18 | 0.96 | 0.19 | 7.2E-07 | 0.55 | 0.11 | 2.2E-06 | 0.09 | 0.03 | 5.2E-04 |
| rs11895934 | 2 | 190510498 | 0.18 | 0.96 | 0.19 | 7.3E-07 | 0.55 | 0.11 | 2.2E-06 | 0.09 | 0.03 | 5.5E-04 | |
| rs7564968 | 2 | 190520217 | 0.18 | 0.96 | 0.19 | 8.0E-07 | 0.55 | 0.11 | 2.3E-06 | 0.09 | 0.03 | 4.9E-04 | |
| rs653178 | 12 | 110492139 | ATXN2 | 0.48 | 0.74 | 0.15 | 8.5E-07 | 0.50 | 0.09 | 2.0E-08 | 0.07 | 0.02 | 7.8E-04 |
| rs284277 | 1 | 10713384 | CASZ1 | 0.35 | 0.79 | 0.16 | 9.4E-07 | 0.24 | 0.09 | 0.01 | 0.09 | 0.02 | 6.9E-05 |
Chr=chromosome; MAF=minor allele frequency; NA=not available DBP=diastolic blood pressure; SBP=systolic blood pressure
Beta is the effect size on blood pressure, in mm Hg, per allele based on the additive genetic model