Table 4.
Meta-analysis of CHARGE and Global BPgen of Top 10 Loci for Systolic and Diastolic Blood Pressure and Hypertension in CHARGE
| CHARGE meta-analysis results | Global BPgen meta-analysis results | CHARGE + Global BPgen meta-analysis | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP identifier | Chr | Position | Nearest Gene | Alleles (coded / other) | Freq. of coded allele | Beta | SE | p-value | Beta | SE | p-value | Beta | SE | p-value |
|
Systolic blood pressure | ||||||||||||||
| rs12046278 | 1 | 10,722,164 | CASZ1 | T/C | 0.64 | -0.84 | 0.18 | 1.84E-06 | -0.29 | 0.15 | 5.71E-02 | -0.53 | 0.12 | 4.77E-06 |
| rs7571613 | 2 | 190,513,907 | PMS1 | A/G | 0.82 | -0.96 | 0.19 | 7.28E-07 | -0.23 | 0.16 | 1.59E-01 | -0.54 | 0.13 | 1.90E-05 |
| rs448378 | 3 | 170,583,593 | MDS1 | A/G | 0.52 | -0.71 | 0.15 | 1.28E-06 | -0.36 | 0.13 | 4.76E-03 | -0.51 | 0.10 | 1.18E-07 |
| rs2736376 | 8 | 11,155,175 | MTMR9 | C/G | 0.13 | -1.08 | 0.23 | 1.90E-06 | -0.06 | 0.19 | 7.36E-01 | -0.48 | 0.15 | 9.15E-04 |
| rs1910252 | 8 | 49,569,915 | EFCAB1 | T/C | 0.18 | -0.93 | 0.19 | 1.70E-06 | -0.07 | 0.17 | 6.80E-01 | -0.43 | 0.13 | 6.13E-04 |
| rs11014166 | 10 | 18,748,804 | CACNB2 | A/T | 0.66 | 0.74 | 0.16 | 2.11E-06 | 0.33 | 0.13 | 1.31E-02 | 0.50 | 0.10 | 7.03E-07 |
| rs1004467 | 10 | 104,584,497 | CYP17A1 | A/G | 0.90 | 1.20 | 0.25 | 1.99E-06 | 0.94 | 0.21 | 1.08E-05 | 1.05 | 0.16 | 1.28E-10 |
| rs381815 | 11 | 16,858,844 | PLEKHA7 | T/C | 0.26 | 0.84 | 0.17 | 5.76E-07 | 0.52 | 0.14 | 2.72E-04 | 0.65 | 0.11 | 1.89E-09 |
| rs2681492 | 12 | 88,537,220 | ATP2B1 | T/C | 0.80 | 1.26 | 0.19 | 3.01E-11 | 0.50 | 0.17 | 4.07E-03 | 0.85 | 0.13 | 3.76E-11 |
| rs3184504 | 12 | 110,368,991 | SH2B3 | T/C | 0.48 | 0.75 | 0.15 | 5.73E-07 | 0.45 | 0.13 | 6.36E-04 | 0.58 | 0.10 | 4.52E-09 |
|
Diastolic blood pressure | ||||||||||||||
| rs13423988 | 2 | 68,764,770 | GPR73/ARHGAP25 | T/C | 0.17 | 0.59 | 0.12 | 1.09E-06 | 0.11 | 0.11 | 3.22E-01 | 0.33 | 0.08 | 5.00E-05 |
| rs13401889 | 2 | 190,618,804 | MSTN | T/C | 0.79 | -0.54 | 0.11 | 9.58E-07 | -0.10 | 0.11 | 3.55E-01 | -0.31 | 0.08 | 4.82E-05 |
| rs9815354 | 3 | 41,887,655 | ULK4 | A/G | 0.17 | 0.60 | 0.12 | 7.88E-07 | 0.40 | 0.11 | 3.79E-04 | 0.49 | 0.08 | 2.54E-09 |
| rs7016759 | 8 | 49,574,969 | EFCAB1 | T/C | 0.83 | 0.57 | 0.12 | 1.87E-06 | 0.06 | 0.11 | 5.79E-01 | 0.30 | 0.08 | 2.29E-04 |
| rs11014166 | 10 | 18,748,804 | CACNB2 | A/T | 0.66 | 0.46 | 0.09 | 8.82E-07 | 0.28 | 0.09 | 1.46E-03 | 0.37 | 0.06 | 1.24E-08 |
| rs11024074 | 11 | 16,873,795 | PLEKHA7 | T/C | 0.72 | -0.50 | 0.10 | 2.83E-07 | -0.17 | 0.09 | 6.82E-02 | -0.33 | 0.07 | 1.20E-06 |
| rs2681472 | 12 | 88,533,090 | ATP2B1 | A/G | 0.83 | 0.64 | 0.12 | 3.74E-08 | 0.36 | 0.12 | 2.43E-03 | 0.50 | 0.08 | 1.47E-09 |
| rs3184504 | 12 | 110,368,991 | SH2B3 | T/C | 0.48 | 0.50 | 0.09 | 1.68E-08 | 0.45 | 0.09 | 2.83E-07 | 0.48 | 0.06 | 2.58E-14 |
| rs2384550 | 12 | 113,837,114 | TBX3/TBX5 | A/G | 0.35 | -0.48 | 0.09 | 1.32E-07 | -0.23 | 0.09 | 1.06E-02 | -0.35 | 0.06 | 3.75E-08 |
| rs6495122 | 15 | 72,912,698 | CSK/ULK3 | A/C | 0.42 | 0.45 | 0.09 | 8.10E-07 | 0.35 | 0.09 | 3.98E-05 | 0.40 | 0.06 | 1.84E-10 |
|
Hypertension | ||||||||||||||
| rs17806132 | 2 | 190,416,532 | PMS1 | A/G | 0.16 | 0.14 | 0.03 | 1.14E-05 | 0.04 | 0.04 | 2.87E-01 | 0.10 | 0.02 | 4.70E-05 |
| rs305489 | 3 | 11,986,163 | SYN2 | A/G | 0.55 | 0.10 | 0.02 | 4.20E-06 | 0.01 | 0.03 | 7.75E-01 | 0.06 | 0.02 | 1.70E-04 |
| rs7640747 | 3 | 37,571,809 | ITGA9 | C/G | 0.62 | -0.12 | 0.02 | 4.53E-07 | -0.02 | 0.03 | 4.12E-01 | -0.08 | 0.02 | 1.24E-05 |
| rs11775334 | 8 | 10,109,030 | MSRA | A/G | 0.32 | 0.10 | 0.02 | 1.03E-05 | 0.05 | 0.03 | 5.86E-02 | 0.08 | 0.02 | 4.05E-06 |
| rs899364 | 8 | 11,366,954 | FAM167A/BLK | T/G | 0.32 | -0.10 | 0.02 | 6.95E-06 | -0.04 | 0.03 | 1.32E-01 | -0.08 | 0.02 | 1.01E-05 |
| rs11014166 | 10 | 18,748,804 | CACNB2 | A/T | 0.66 | 0.11 | 0.02 | 7.96E-07 | 0.07 | 0.03 | 1.06E-02 | 0.09 | 0.02 | 5.72E-08 |
| rs2681472 | 12 | 88,533,090 | ATP2B1 | A/G | 0.83 | 0.16 | 0.03 | 1.65E-08 | 0.13 | 0.04 | 2.15E-04 | 0.15 | 0.02 | 1.75E-11 |
| rs278126 | 12 | 118,620,100 | CIT | T/G | 0.28 | 0.11 | 0.02 | 8.34E-06 | -0.01 | 0.03 | 6.72E-01 | 0.06 | 0.02 | 1.74E-03 |
| rs11612893 | 12 | 129,290,572 | FZD10/PIWIL1 | T/G | 0.10 | -0.19 | 0.04 | 7.62E-06 | -0.04 | 0.06 | 4.19E-01 | -0.14 | 0.03 | 5.50E-05 |
| rs16982520 | 20 | 57,192,115 | ZNF831/ EDN3 | A/G | 0.88 | -0.14 | 0.03 | 4.95E-06 | -0.11 | 0.04 | 7.44E-03 | -0.13 | 0.02 | 1.59E-07 |
Chr=chromosome;
SNPs in bold attained p <5×10-8 in meta-analysis of CHARGE and Global BPgen