Table 1.

Animal studies of belatacept in solid organ transplantation

Animal model	Transplant organ	Drug combination	Median survival
Rhesus monkey26	Renal allograft	Abatacept monotherapy	8 days
		Belatacept monotherapy	35 days
		Belatacept/MMF/steroids	155 days
		Basiliximab induction; belatacept	>100 days
Rhesus monkey51	Islet allograft	Anti-CD40 monotherapy	16 days
		Belatacept monotherapy	59 days
		Belatacept/anti-CD40	220 days
Rhesus monkey52	Neonatal islet xenograft	Basiliximab + anti-CD154 induction; belatacept + sirolimus	>140 days
Rhesus monkey53	Adult islet xenograft	Basiliximab + anti-CD154 induction; belatacept + sirolimus	2/5 (20%) engraftment

Abbreviation: MMF, mycophenolate mofetil.