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. Author manuscript; available in PMC: 2011 Apr 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Jan 7;30(4):694–701. doi: 10.1161/ATVBAHA.109.200741

Figure 5. Loss of CRP1 attenuates neointima formation in response to guide-wire induced arterial injury.

Figure 5

(A) Analysis of genotypes from Csrp1+/− Csrp2−/− intercrosses demonstrates that Csrp1−/− Csrp2−/− mice are viable. (B–E) Sections of femoral arteries from mice subjected to guide-wire induced arterial injury, sacrificed 2 weeks after injury. As compared to wild type (B), Csrp1-null mice (C) showed significantly reduced neointima formation. Increased neointima formation in Csrp2-null mice is also shown as reference (D; 6). Note that neointima formation in Csrp1−/− Csrp2−/− double null was decreased (E), compared to Csrp2-null. (F) Quantification of the intima/media ratio demonstrates a statistically significant difference in the response of Csrp1-null (n=16) and Csrp2-null (n=11) verses wildtype (n=12), and Csrp2-null verses Csrp1−/− Csrp2−/− double-null (n=10). *p<0.05 by ANOVA.