Fig. 5.

Expression of beclin 1 protein in tumors from beclin 1^+/- mice. (a) Western blot analysis of cell extracts from tumors with anti-beclin 1 antibody or anti-Ran antibody (control). Lane 1, cell lysate from wt spleen; lanes 2–4, B cell lymphomas; lane 5, lung adenocarcinoma; lane 6, heptocellular carcinoma. (Lower) Ran protein level in each lane as loading control. (b) Section from B cell lymphoma stained with (Left) or without (Right) anti-beclin 1 antibody. (c) Section from lung adenocarcinoma stained with (Left) or without (Right) anti-beclin 1 antibody. (Scale bar, 20 μm.)