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Pharmackinetics of HIIC with melphalan. Pharmacokinetic profile of melphalan given intraperitoneally at 70 mg/m2 in 3 L of 1.5% dextrose peritoneal dialysis solution at 42°C for 90 min. Pharmacokinetic studies showed that the drug concentration in the tumor nodules was approximately 30% of the intraperitoneal concentration and 10 times the plasma concentration.
