Fig. 6.

Prolonged survival in mice with advanced ALL receiving rapamycin as a single agent. Eμ-ret transgenic mice with overt disease were treated daily i.p. with rapamycin (5 mg/kg per dose), as described in Materials and Methods. This Kaplan-Meier analysis of event-free survival (EFS) shows the fraction of animals surviving after the onset of disease. Rapamycin doubled the mean survival time of leukemic mice. The average time from diagnosis to death was 32 days in treated mice (n = 34) and 15 days in untreated mice (n = 23) (P < 0.00001).