Table 1.
Experimentally determined tyrosine-phosphorylated effectors and their motifs
| Effector | Pathogen | Locus of protein | Motif (phosphorylated Y position) | |||||
|---|---|---|---|---|---|---|---|---|
| CagA | H.Ppylori | NP_207343 | EPIYAKVNK | Y-899 | EPIYTQVAK | Y-918 | EPIYATIDD | Y-972 |
| Ankyrin | Anaplasma phagocytophilum | ABB84853 | ESIYEEIKD | Y-940 | ESIYEEIKD | Y-967 | ESIYEEIKD | Y-994 |
| EDLYATVGA | Y-1028 | ESIYADPFD | Y-1056 | ESIYADPFA | Y-1074 | |||
| EPIYATVKK | Y-1098 | |||||||
| BepD | Bartonella henselae | YP_034066 | EPLYAQVNK | Y-32 | NPLYEGVGG | Y-114 | NPLYEGVGS | Y-176 |
| EPLYAQVNK | Y-211 | NPLYEGVGG | Y-293 | NPLYEGVGP | Y-355 | |||
| BepE | Bartonella henselae | YP_034067 | EPLYATVNK | Y-37 | ETIYTTVSS | Y-91 | ||
| BepF | Bartonella henselae | YP_034068 | TPLYATPSP | Y-149 | EPLYATPLP | Y-213 | EPLYATPLP | Y-241 |
| EPLYATAAP | Y-297 | EPLYATPLP | Y-269 | |||||
| Tir | Escherichia Eoli | AAC38390 | EHIYDEVAA | Y-474 | ||||
| Tir | Citrobacter rodentium | AAL06376 | EPIYDEVAP | Y-468 | ||||
| Trap | Chlamydie trachomatis | YP_001654788 | ENIYENIYE | Y-136 | ENIYENIYE | Y-238 | ENIYENIYE | Y-390 |
CagA: cytotoxin associated gene A [7,8,10,52-56]; BepD: Bartonella henselae protein D [14-16,57]; BepE: Bartonella henselae protein E [14-16,57]; BepF: Bartonella henselae protein F [14-16,57]; Tir: translocated intimin receptor [58-60] ; Trap: Translocated actin-recruiting protein [61-63] . The first five amino acids of the listed sequences in the table correspond to the EPIYA motif.