Figure 7.

Progestins and antiprogestins differentially regulate the expression of NF-κB-activated genes. A, Dendogram showing expression profiles of endogenous NF-κB target genes upon progestin and antiprogestin treatment. A gene expression profile of 66 genes was generated using T47D-A18 cells treated with R5020, RU486 with or without IL-1β, and R5020 plus RU486. RNA was harvested for cDNA production and real-time PCR analysis. The profiles were analyzed by the Ward hierarchical clustering algorithm using standardized data. Ctl, Control.