Table 1.
Physiological characteristics and serum chemistry of Hnf1a-null mice
| Wild-type | Hnf1a-null | Ratioa | P value | |
|---|---|---|---|---|
| Body mass (g) | 23.3 ± 0.62 | 11.0 ± 0.97 | 0.47 | <0.0001 |
| Liver/body mass (mg/g) | 51.9 ± 0.87 | 145 ± 4.35 | 2.80 | <0.0001 |
| Kidney/body mass (mg/g) | 9.56 ± 0.14 | 13.2 ± 0.87 | 1.38 | <0.0001 |
| Adrenal gland/body mass (mg/g) | 0.13 ± 0.01 | 0.36 ± 0.03 | 2.77 | <0.0001 |
| Diuresis (μl/g · 24 h) | 43.6 ± 3.30 | 74.7 ± 20.0 | 1.71 | 0.02 |
| Serum chemistry analysis | ||||
| Na+ (mmol/liter) | 154.3 ± 2.84 | 148.7 ± 3.18 | 0.96 | 0.25 |
| K+ (mmol/liter) | 7.57 ± 0.20 | 6.50 ± 0.26 | 1.16 | 0.02 |
| Glucose, fed (mg/dl) | 180.0 ± 8.10 | 239.7 ± 18.80 | 1.33 | 0.02 |
| Phosphorous (mg/dl) | 9.30 ± 0.25 | 8.53 ± 0.57 | 0.92 | 0.23 |
| Blood urea nitrogen (mg/dl) | 28.75 ± 1.65 | 32.33 ± 1.86 | 1.12 | 0.21 |
| Amylase (U/liter) | 1318 ± 79.23 | 1603 ± 81.42 | 1.21 | 0.06 |
| Ca2+ (mg/dl) | 10.95 ± 0.12 | 10.53 ± 0.32 | 0.96 | 0.22 |
| Globulin (g/dl) | 1.95 ± 0.03 | 1.57 ± 0.03 | 0.81 | 0.0003 |
| Total protein (g/dl) | 6.10 ± 0.08 | 5.30 ± 0.21 | 0.86 | 0.01 |
| Alanine aminotransferase (U/liter) | 87.25 ± 13.96 | 224.0 ± 68.57 | 2.57 | 0.07 |
| Alkaline phosphatase (U/liter) | 156.8 ± 13.0 | 870.3 ± 63.6 | 5.55 | <0.0001 |
| Albumin (g/dl) | 4.12 ± 0.05 | 3.73 ± 0.18 | 0.90 | 0.06 |
| Total bilirubin (mg/dl) | 0.23 ± 0.03 | 0.90 ± 0.35 | 3.91 | 0.07 |
a
Ratio of Hnf1a-null value to wild-type value.