Skip to main content
. 2010 Oct 20;151(12):5916–5926. doi: 10.1210/en.2010-0165

Figure 5.

Figure 5

Effects of stmPRα and PR levels on progestin inhibition of serum starvation-induced cell death. All data represent means ± sem. A, G/T cell serum starvation-induced death in response to 20β-S after transfection with siRNA directed against croaker mPRα or control pool after 6 d of treatment with 10 nm 20β-S. **, P < 0.05 compared with vehicle (Veh) control by one-way ANOVA with Dunnett’s multiple comparison, n = 9. B, Croaker mPRα mRNA and protein levels after treatment with siRNA directed against mPRα or control pool siRNA. C, G/T cell serum starvation-induced death in response to 20β-S after transfection with siRNA directed against croaker PR or control pool after 8 d of treatment with 10 nm 20β-S. Inset shows PCR demonstrating reduced levels of PR mRNA. **, P < 0.05 compared with vehicle control by one-way ANOVA with Dunnett’s multiple comparison, n = 9. D, Changes in the rate of serum starvation-induced cell death of MDA-MB-231 cells stably transfected with stmPRα or vector alone in response to a 48-h exposure to 10 nm 20β-S or R5020. **, P < 0.001 compared with vehicle control by one way ANOVA with Dunnett’s multiple comparison, n = 6.