Table 1.
Micro-CT measurements of vertebral trabecular bone
| BV/TV (%) | Trabecular number (1/mm) | Trabecular thickness (μm) | Connective density (1/mm3) | Tissue density (mg/ccmHA) | SMI | BS/BV (1/mm) | |
|---|---|---|---|---|---|---|---|
| Placebo (n = 9) | 21.2 ± 1.37 | 4.23 ± 0.16 | 49.64 ± 1.36 | 199.05 ± 14.43 | 1083.17 ± 8.60 | 0.96 ± 0.17 | 45.50 ± 1.54 |
| Lactation (n = 10) | 14.7 ± 1.24 | 4.4 ± 0.29 | 40.38 ± 0.80 | 253.33 ± 35.66 | 1045.81 ± 6.22 | 1.64 ± 0.11 | 60.52 ± 1.63 |
| Leuprolide (n = 10) | 22.7 ± 1.94 | 4.59 ± 0.15 | 51.05 ± 1.41 | 195.58 ± 12.91 | 1089.12 ± 2.54 | 0.86 ± 0.20 | 44.38 ± 1.78 |
| PTHrP (n = 10) | 19.6 ± 1.23 | 4.32 ± 0.22 | 46.0 ± 0.96 | 283.0 ± 42.34 | 1036.0 ± 11.24 | 1.1 ± 0.09 | 50.2 ± 1.31 |
| PTHrP/leuprolide (n = 11) | 21.1 ± 1.2 | 4.16 ± 0.23 | 48.68 ± 1.04 | 218.66 ± 11.67 | 1053.31 ± 6.23 | 0.78 ± 0.13 | 46.35 ± 1.54 |
| OVX (n = 10) | 20.1 ± 1.07 | 3.87 ± 0.17 | 51.04 ± 1.39 | 149.12 ± 10.08 | 1098.26 ± 12.32 | 0.86 ± 0.12 | 44.17 ± 1.47 |
| PTHrP/OVX (n = 9) | 21.9 ± 1.96 | 4.66 ± 0.24 | 48.90 ± 2.17 | 260.28 ± 33.75 | 1042.40 ± 16.22 | 0.98 ± 0.21 | 47.98 ± 2.57 |
The chart contains the mean ± sem of trabecular parameters measured on the third lumbar vertebra on mice from the various treatment groups. All measurements were compared against the same parameter assessed on placebo-treated mice. Statistically significant differences (P < 0.05) are denoted in bold type. The number of mice in each group is noted on the chart. ccmHA, Cubic centimeters of hydroxyapatite.