Table 2.
Micro-CT measurements of femur trabecular bone
| BV/TV (%) | Trabecular number (1/mm) | Trabecular thickness (1/mm) | Connective density (1/mm3) | Tissue density (mg/ccmHA) | SMI | BS/BV (1/mm) | |
|---|---|---|---|---|---|---|---|
| Placebo (n = 5) | 0.16 ± 0.017 | 4.79 ± 0.18 | 0.045 ± 0.002 | 263.75 ± 26.28 | 818.95 ± 5.62 | 1.57 ± 0.13 | 59.48 ± 2.81 |
| Lactation (n = 5) | 0.09 ± 0.012 | 4.08 ± 0.58 | 0.038 ± 0.001 | 221.12 ± 47.14 | 781.50 ± 12.67 | 2.09 ± 0.07 | 74.02 ± 1.76 |
| Leuprolide (n = 5) | 0.17 ± 0.006 | 4.83 ± 0.11 | 0.049 ± 0.001 | 242.59 ± 18.59 | 826.23 ± 4.97 | 1.49 ± 0.07 | 55.04 ± 1.19 |
| PTHrP (n = 5) | 0.12 ± 0.013 | 3.63 ± 0.21 | 0.050 ± 0.003 | 173.03 ± 24.51 | 803.37 ± 9.71 | 1.65 ± 0.15 | 57.28 ± 3.34 |
| PTHrP/leuprolide (n = 5) | 0.15 ± 0.033 | 4.47 ± 0.61 | 0.044 ± 0.003 | 274.01 ± 54.48 | 765.84 ± 19.48 | 1.65 ± 0.28 | 62.99 ± 5.31 |
| OVX (n = 5) | 0.15 ± 0.008 | 3.87 ± 0.21 | 0.047 ± 0.0004 | 377.24 ± 55.17 | 870.63 ± 6.89 | 1.19 ± 0.08 | 56.08 ± 0.75 |
| PTHrP/OVX (n = 5) | 0.16 ± 0.032 | 4.56 ± 0.51 | 0.040 ± 0.002 | 550.28 ± 100.64 | 815.42 ± 9.19 | 1.44 ± 0.27 | 68.79 ± 4.97 |
The chart contains the mean ± sem of trabecular parameters measured in the distal femoral metaphasis on mice from the various treatment groups. All measurements were compared against the same parameter assessed on placebo-treated mice. Statistically significant differences (P < 0.05) are denoted in bold type. The number of mice in each group is noted on the chart. ccmHA, Cubic centimeters of hydroxyapatite.