Table 3.
Micro-CT measurements of femur cortical bone
| BV/TV (%) | Tissue density (mg/ccmHA) | BS/BV (1/mm) | Cortical thickness (mm) | Outer circumference (mm) | Inner circumference (mm) | |
|---|---|---|---|---|---|---|
| Placebo (n = 5) | 0.91 ± 0.0057 | 976.22 ± 13.23 | 10.70 ± 0.32 | 0.19 ± 0.005 | 5.26 ± 0.10 | 4.09 ± 0.12 |
| Lactation (n = 5) | 0.89 ± 0.008 | 1023.11 ± 12.82 | 11.31 ± 0.46 | 0.18 ± 0.007 | 5.23 ± 0.16 | 4.12 ± 0.16 |
| Leuprolide (n = 5) | 0.92 ± 0.005 | 996.27 ± 19.59 | 10.54 ± 0.42 | 0.19 ± 0.007 | 5.34 ± 0.06 | 4.15 ± 0.80 |
| PTHrP (n = 5) | 0.91 ± 0.004 | 1039.94 ± 6.12 | 10.85 ± 0.27 | 0.18 ± 0.005 | 5.39 ± 0.09 | 4.23 ± 0.11 |
| PTHrP/leuprolide (n = 5) | 0.88 ± 0.012 | 964.37 ± 10.33 | 14.36 ± 1.22 | 0.14 ± 0.012 | 5.52 ± 0.09 | 4.62 ± 0.05 |
| OVX (n = 5) | 0.92 ± 0.003 | 1048.85 ± 14.17 | 9.96 ± 0.16 | 0.20 ± 0.003 | 5.17 ± 0.12 | 3.91 ± 0.14 |
| PTHrP/OVX (n = 5) | 0.89 ± 0.007 | 1014.61 ± 31.57 | 12.75 ± 0.62 | 0.16 ± 0.008 | 5.50 ± 0.16 | 4.51 ± 0.18 |
The chart contains the mean ± sem of cortical parameters measured in the femoral shaft on mice from the various treatment groups. All measurements were compared against the same parameter assessed on placebo-treated mice. Statistically significant differences (P < 0.05) are denoted in bold type. The number of mice in each group is noted on the chart. ccmHA, Cubic centimeters of hydroxyapatite.