Table 4.
Static histomorphometry of vertebral bone
| BV/TV (%) | TbTh (μm) | Nob/TAR (1/mm2) | Nob/Bpm (1/mm) | Noc/TAR (1/mm2) Noc/Bpm (1/mm) | Placebo (n = 7) | |
|---|---|---|---|---|---|---|
| Lactation (n = 8) | 25.39 ± 1.41 | 28.46 ± 1.48 | 345.89 ± 43.58 | 24.74 ± 3.11 | 25.46 ± 1.17 | 1.84 ± 0.13 |
| Leuprolide (n = 8) | 32.20 ± 1.85 | 34.84 ± 1.14 | 184.31 ± 38.61 | 12.92 ± 2.57 | 30.76 ± 2.30 | 2.11 ± 0.10 |
| PTHrP (n = 8) | 32.52 ± 0.75 | 34.39 ± 0.96 | 470.67 ± 53.64 | 31.35 ± 3.02 | 30.18 ± 3.33 | 2.01 ± 0.19 |
| PTHrP/leuprolide (n = 8) | 32.54 ± 0.95 | 32.69 ± 1.07 | 369.71 ± 62.25 | 23.24 ± 3.70 | 33.81 ± 2.30 | 2.16 ± 0.13 |
| OVX (n = 8) | 30.37 ± 1.93 | 35.18 ± 1.52 | 156.25 ± 23.85 | 11.58 ± 1.72 | 27.46 ± 3.49 | 2.03 ± 0.24 |
| PTHrP/OVX (n = 7) | 27.66 ± 2.10 | 30.72 ± 0.71 | 186.85 ± 23.84 | 13.46 ± 1.90 | 37.79 ± 6.34 | 2.60 ± 0.34 |
The chart contains the mean ± sem of histomorphometric measurements of bone volume and osteoclast and osteoblast numbers in the first and second lumbar vertebrae of mice from the various groups listed in the chart. All measurements were compared against the same parameter assessed on placebo-treated mice. Statistically significant differences (P < 0.05) are denoted in bold type. The number of mice in each group is noted on the chart. TbTh, Trabecular thickness; Nob/TAR, number of ostéoblasts per tissue area; Nob/Bpm, number of osteoblasts per bone perimeter; Noc/TAR, number of osteoclasts per tissue area; Noc/Bpm, number of osteoclasts per bone perimeter.