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. 2010 Oct 6;151(12):5741–5750. doi: 10.1210/en.2010-0672

Figure 5.

Figure 5

Hepatic insulin sensitivity. A, In 16-wk-old male mice after HFD, basal HGP is significantly elevated in IGFBP-3−/− mice, but no differences were observed during insulin stimulation (n = 7–8 per group); B, during insulin stimulation, PEPCK was suppressed in the KO compared with WT as detected with immunoblotting (inset) and densitometric analyses; C, glucose infusion rate was not significantly different (n = 7–8 per group); D, no differences in total and insulin-stimulated glucose disposal rate (n = 7–8 per group); E, 16-wk-old male IGFBP-3−/− mice have greater quadriceps (Quad) and tibialis anterior (Tib Ant) muscle mass in the fasted state (n = 8–11 per group). *, P < 0.05. Means ± sem are presented.