Table 2. Diagnostic utility of peripheral neuropathy screening tools and quantitative sensory testing in detecting moderate to severe peripheral neuropathy.

	Sensitivity [95%CI]	Specificity [95%CI]	PPV	NPV	Acc	LR+	LR-	AUC	Cutoff
Neuropathy Severity Score	66.7 [29, 104]	91.7 [81, 103]	66.7	91.7	86.7	8	0.4	0.83	≥6
Subjective-PNS – Maximum Score	66.7 [29, 104]	91.7 [81, 103]	66.7	91.7	86.7	8	0.4	0.83	≥5
Subjective-PNS) - Total Score	83.3 [53, 113]	83.3 [68, 98]	55.6	95.2	83.3	5	0.2	0.86	≥6
Single Question Neuropathy Screen	83.3 [53, 113]	70.8 [53, 89]	41.7	94.4	73.3	2.9	0.2	0.77	----
Brief-PNS	0 [0,0]	91.7 [81, 103]	0	78.6	73.3	0	1.1	0.46	----
Monofilament	100 [100,100]	87.5 [74, 101]	66.7	100	90	8	0	0.94	≥2
Graduated Tuning Fork	83.3 [53, 113]	87.5 [74, 101]	62.5	95.4	86.7	6.7	0.2	0.85	----
Two-Point Discrimination	75 [40, 109]	58.3 [39, 78]	23.1	93.3	60.7	1.8	0.4	0.70	≥4

Abbreviations: Acc: Accuracy; PNS: Peripheral Neuropathy Screen.