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. 2010 Dec 8;5(12):e15211. doi: 10.1371/journal.pone.0015211

Figure 6. Embryonic retinal pharmacologic manipulation modifies cortical layer 4.

Figure 6

(a) BrdU+ neurons in P0 cortices treated at E15.5 are increased in contralateral epibatidine-treated cortices. (b) Quantification of BrdU+ neurons after treatment with epibatidine (V1 vs S1 n = 4, p = 0.0072, Student's t-test, two samples equal variants). (c) Rorβ in situ hybridization in P0 animals treated at E15.5: layer 4 (IV) expression is increased in epibatidine treated compared to internal control cortices (ipsilateral; upper panels). Right and left panels represent a higher magnification of highlighted boxes in the middle panel (n = 6). Abbreviations: AuD auditory cortex, Pt parietal cortex, V1 primary visual cortex, V2L secondary visual cortex (lateral area), V2M secondary visual cortex (medial area) and WM, white matter.