Table 2.
Selected results from logistic regression and BMA.
| Variable | Logistic regression | BMA | |||||
|---|---|---|---|---|---|---|---|
| Pointwise | Modelmaina | Modelallb | |||||
| OR (95% CI) | OR (95% CI) | OR (95% CI) | OR (95% CI)& | OR|I = 1 (95% CI)$ | Prpost | BF(I = 1) | |
| packyears | 1.08 (1.00-1.16)* | 1.08 (1.01-1.16)* | 1.09 (1.01-1.17)* | 1.01 (1.01-1.01) | 1.08 (1.08-1.08) | 0.13 | 0.43 |
| NAT1 *10 | 1.21 (1.01-1.44)* | 1.18 (0.98-1.42)# | 1.21 (1.00-1.46)# | 1.05 (1.05-1.05) | 1.19 (1.19-1.20) | 0.26 | 1.05 |
| NAT2 slow vs fast1 | 0.86 (0.70-1.04) | 0.90 (0.73-1.11) | 0.89 (0.72-1.09) | 0.98 (0.98-0.98) | 0.87 (0.87-0.88) | 0.13 | 0.45 |
| CYP1A1 *12 | 0.96 (0.77-1.21) | 0.94 (0.74-1.18) | 0.92 (0.73-1.16) | 1.00 (1.00-1.00) | 0.96 (0.96-0.97) | 0.06 | 0.19 |
| GSTT1 deletion | 0.84 (0.65-1.10) | 0.86 (0.66-1.12) | 0.86 (0.66-1.13) | 0.98 (0.98-0.98) | 0.86 (0.86-0.86) | 0.12 | 0.42 |
| GSTM1 deletion | 1.13 (0.93-1.37) | 1.15 (0.94-1.40) | 1.16 (0.95-1.42) | 1.01 (1.01-1.01) | 1.12 (1.12-1.13) | 0.09 | 0.31 |
| CYP1B1 *3 | 0.90 (0.78-1.03) | 0.90 (0.78-1.04) | 0.90 (0.78-1.04) | 0.99 (0.99-0.99) | 0.91 (0.90-0.91) | 0.09 | 0.31 |
| packyears × NAT2 | 1.19 (1.03-1.38)* | 1.20 (1.03-1.40)* | 1.00 (1.00-1.00) | 1.19 (1.18-1.20) | 0.01 | 0.30 | |
| packyears × GSTM1 | 1.11 (0.96-1.28) | 1.11 (0.96-1.29) | 1.00 (1.00-1.00) | 1.10 (1.08-1.12) | 0.00 | 0.07 | |
Adjusted for age, menopause and family history
1 slow acetylators had at least one *4 allele
2 the reference was homozygote for the *1 allele
a only main effects
b all main effects and interactions
&OR and CI computed from mean coefficient estimate and its standard error averaged over all models
$ OR and CI computed from mean coefficient estimate and its standard error averaged over all models containing the respective variable
# p < 0.1, * p < 0.05