Table 1.
Fold change in expression of metabolism genes
| HCT116 versus | |||
|---|---|---|---|
| Gene symbol | HCT116HIF-1α-/- | HCT116HIF-2α-/- | HCT116HIF-1α-/-HIF-2α-/- |
| ACAT2 | 1.435 | 1.346 | 3.037 |
| GSTP1 | 1.416 | 1.257 | 2.552 |
| G6PD | 1.068 | 1.144 | 5.369 |
| METTL7B | 1.723 | 0.758 | 2.947 |
| GSTM4 | 1.519 | 0.667 | 2.643 |
| NAT1 | 1.799 | 0.857 | 2.513 |
| SULF2 | 1.047 | 0.584 | 3.444 |
| UGT8 | 0.833 | 0.543 | 2.312 |
| PCAF | 1.131 | 0.617 | 3.6 |
| ABP1 | 1.17 | 1.524 | 7.443 |
| ALPP | 1.193 | 2.608 | 5.763 |
| METTL7A | 0.831 | 1.017 | 2.359 |
| MDH1B | 0.915 | 0.943 | 2.237 |
| MAN1C1 | 1.333 | 0.775 | 2.076 |
| CRYZL1 | 1.214 | 0.756 | 2.252 |
| LSS | 1.103 | 0.898 | 2.052 |
| HIBCH | 1.021 | 0.757 | 2.094 |
| SRR | 0.988 | 0.598 | 2.04 |
| ZADH2 | 0.665 | 0.725 | 2.381 |
| TP53I3 | 1.116 | 1.06 | 3.215 |
| ALPPL2 | 0.887 | 1.537 | 3.467 |
| ALDH7A1 | 0.985 | 1.215 | 2.211 |
| ACAA2 | 1.1 | 1.466 | 2.539 |
| DHRS2 | 5.301 | 0.304 | 2.496 |
| DHRS3 | 0.492 | 0.515 | 0.306 |
| DPYD | 0.445 | 0.268 | 0.251 |
| ASNS | 0.646 | 0.816 | 0.126 |
| BCKDHA | 0.544 | 0.944 | 0.315 |
| PCK2 | 0.661 | 0.798 | 0.214 |
| TMEM68 | 0.849 | 1.18 | 0.38 |
| ALDOC | 0.62 | 1.178 | 0.301 |
| PSAT1 | 0.787 | 0.98 | 0.257 |
| ATP9A | 0.71 | 0.445 | 0.257 |
| RDHE2 | 0.841 | 0.405 | 0.443 |
| MOCOS | 0.797 | 0.419 | 0.361 |
| PHGDH | 0.391 | 0.738 | 0.321 |
| ACSM3 | 0.448 | 0.512 | 0.488 |
| ACSS2 | 0.603 | 0.717 | 0.371 |
| MTHFD1L | 0.574 | 0.99 | 0.378 |
| GAA | 0.726 | 0.474 | 0.464 |
| GFPT1 | 0.793 | 0.644 | 0.499 |
| UAP1 | 0.99 | 0.886 | 0.406 |
| AGPAT7 | 1.028 | 0.757 | 0.428 |
| PLD3 | 0.96 | 0.651 | 0.453 |
| PLA2G4C | 1.301 | 0.608 | 0.37 |
| LIAS | 1.213 | 0.897 | 0.493 |
| PYCR1 | 1.005 | 0.76 | 0.444 |
| MECR | 0.858 | 0.766 | 0.494 |
| ACSL5 | 0.228 | 0.334 | 0.055 |
| MMP1 | 0.395 | 0.07 | 0.059 |
Note: expression values are normalized to those in HCT116 cells.