Fig. 3.

IDO is not critical for carcinogenesis in the absence of an explicit pro-inflammatory driver. a IDO is not critical for skin carcinogenesis in the absence of TPA-induced inflammation. Mice were enrolled on the standard protocol of complete carcinogenesis involving repetitive exposure to carcinogen DMBA alone and tumor incidence was determined. Standard error in the data presented is shown. b IDO is not critical for DMBA-induced mammary carcinogenesis. Mice were enrolled on a standard protocol of mammary carcinogenesis involving i.p. administration of DMBA and continuous exposure to the progesterone mimetic medroxyprogesterone acetate. WT, wild-type mice; KO, Ido1 ^−/− mice. (n = 10 all groups)