Table 1.

Scoring system for the diagnosis of AIH [8]

Category	<Factor	Score
Gender	<female	+2
Alk phos: AST (or ALT) ratio	>3	−2
	<1.5	+2
γ-Globulin or IgG (times above upper limit of normal)	>2.0	+3
	1.5–2.0	+2
	1.0–1.5	+1
	<1.0	0
ANA, SMA, or anti-LKM1 titers	>1:80	+3
	1:80	+2
	1:40	+1
	<1:40	0
AMA	positive	−4
Viral markers of active infection	positive	−3
	negative	+3
Hepatotoxic drugs	yes	−4
	no	+1
Alcohol	<25 g/d	+2
	>60 g/d	−2
Concurrent immune disease	any nonhepatic disease of an immune nature	+2
Other autoantibodiesa	anti-SLA/LP, actin, LC1, pANCA	+2
Histologic features	interface hepatitis	+3
	plasma cells	+1
	rosettes	+1
	none of above	−5
	biliary changesb	−3
	atypical featuresc	−3
HLA	DR3 or DR4	+1
Treatment response	remission alone	+2
	remission with relapse	+3
Pretreatment score
Definite diagnosis		>15
Probable diagnosis		10–15
Posttreatment score
Definite diagnosis		>17
Probable diagnosis		12–17

Alk phos = serum alkaline phosphatase level; ALT = serum alanine aminotransferase level; AMA = antimitochondrial antibodies; ANA = antinuclear antibodies; AST = serum aspartate aminotransferase level; HLA = human leukocyte antigen; IgG = serum immunoglobulin G level; anti-LKM1 = antibodies to liver/kidney microsome type 1; SMA = smooth muscle antibodies; HLA-DR3, DR4 = human leukocyte antigen-D.

Data from [17].

^aUnconventional or generally unavailable antibodies associated with liver disease include perinuclear antineutrophil cytoplasmic antibodies (pANCA) and antibodies to actin, soluble liver antigen/liver pancreas (anti-SLA/LP), asialoglycoprotein receptor, and liver cytosol type 1 (LC1).

^bIncludes destructive cholangitis, nondestructive cholangitis, or ductopenia.

^cIncludes steatosis, iron overload consistent with genetic hemochromatosis, alcoholic hepatitis, viral features (ground-glass hepatocytes), or inclusions (cytomegalovirus, herpes simplex).