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Physiologic gastric protein digestion by pepsin. After activation of pepsin, the substrate-binding cleft is accessible for proteins, and protein cleavage into peptides takes place. The figure was created with the program Protein Explorer 2.411 Beta (available at: http://proteinexplorer.org) by using the structural information of porcine pepsin provided with the Research Collaboratory for Structural Bioinformatics Protein Data Bank accession number 5PEP.
