TABLE I.

Drug action mechanisms of acid-suppression medication

Active substance	Mechanism of gastric acid suppression
Antacids	Slight bases neutralizing gastric acid
Sucralfate	Aluminum compound acquiring a strong negative charge on aluminum release, binds to positive charges in its environment
H2-receptor blocker	Antagonist for the stimulating effect of histamine through its H2-receptor on the basolateral surface of parietal cells
PPI	Potent, irreversible blocker of the acid pump function (H+, K+, ATPase) on parietal cells