Table 2. Observed and simulated VNTR variation for spoligotype SB0140.
| No. of isolates in
|
No. of genotypes
|
|||||
|---|---|---|---|---|---|---|
| Root* | dbar | Ancestral genotype | Five largest mutant genotypes | 1–2 isolates | >2 isolates | |
| Observed† | 7-5-5-4 | 1.28 | 197 | 900 | 11 | 11 |
| 6-5-5-4 | 1.48 | 358 | 739 | 11 | 11 | |
| Simulation‡ | ||||||
| Star phylogeny | 1.3 | 252 | 218 | 95 | 81 | |
| Branching phylogeny | 1.28 | 164 | 268 | 79 | 78 | |
*
Sample of 1,169 isolates with spoligotype SB0140 from Great Britain
†
7-5-5-4 is the preferred root because it minimizes the mean genetic distance, dbar, to all other isolates. 6-5-5-4 is the most common VNTR type
‡
Simulations are a sample of 1,169 from a simulated population of 8,000–10,000, with the number of generations and mutation rate chosen to give the observed value of dbar