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. 2011 Jan;52(1):98–103. doi: 10.1194/jlr.M009480

Fig. 1.

Fig. 1.

Effect of PI3K inhibitors on induction of electrophilic genes and NRF2 by OxPAPC. A: GCLM mRNA was quantified in HUVECs stimulated with OxPAPC (130 µmol/l for 6 h) in the presence or absence of Wort (1 µmol/l or LY294002 (30 µmol/l). GCLM mRNA expression was quantified by real-time qPCR and normalized to β2-microglobulin mRNA levels. B, C: Effect of Wort and LY294002 on induction of NQO1 and HO-1 mRNAs levels by OxPAPC was studied as described above. D: Analysis of effects of Wort (1 µmol/l) and LY294002 (30 µmol/l) on the levels of NRF2 upon stimulation with OxPAPC (130 µmol/l, 2 h). Cell lysates were probed by Western blotting with antibodies against NRF2.