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. 2010 Dec 1;4:133–141. doi: 10.4137/CMO.S4364

Table 1.

Pharmacokinetic parameter values (mean ± SD) for nelarabine, ara-G, ara-GTP.¹²–¹⁴

	Pediatric	Adult
Nelarabine
Vd (L)	8.511 ± 11.518	4.197 ± 5.802	NS^a
CL (L/kg/hr)	9.259 ± 12.794	5.875 ± 8.434	NS^a
t½ (minutes)	14.1^b	16.5^b	NS^a
ara-G
Vd (L)	1.023 ± 0.345	0.923 ± 0.231	NS^a
CL (L/kg/hr)	0.312 ± 0.112	0.213 ± 0.072	P < 0.0001
t½ (hrs)	2.1^b	3.0^b	P < 0.01
ara-GTP
Mean ara-GTP (μM)		435 ± 519
		746 ± 872^c
t½ (hrs)	>24^b ^d

Notes:

^a

No statistical difference;

^b

Harmonic mean value;

^c

Nelarabine following fludarabine (combination);

^d

Patient with T-cell disease.