Table 1.
Pediatric | Adult | ||
---|---|---|---|
Nelarabine | |||
Vd (L) | 8.511 ± 11.518 | 4.197 ± 5.802 | NSa |
CL (L/kg/hr) | 9.259 ± 12.794 | 5.875 ± 8.434 | NSa |
t½ (minutes) | 14.1b | 16.5b | NSa |
ara-G | |||
Vd (L) | 1.023 ± 0.345 | 0.923 ± 0.231 | NSa |
CL (L/kg/hr) | 0.312 ± 0.112 | 0.213 ± 0.072 | P < 0.0001 |
t½ (hrs) | 2.1b | 3.0b | P < 0.01 |
ara-GTP | |||
Mean ara-GTP (μM) | 435 ± 519 | ||
746 ± 872c | |||
t½ (hrs) | >24bd |
Notes:
No statistical difference;
Harmonic mean value;
Nelarabine following fludarabine (combination);
Patient with T-cell disease.