Table 1.

Early detection of breast cancer.

Study	MS Method	Study Size N =	Sensitivity	Specificity	External Validation?
Hu et al. The Breast 2005 [52]	SELDI-TOF	49 BC 51 BBD 33 HC	83.33%	88.89%	Yes N = 18 BC, 9HC
Fan et al. Journal of Cancer Research and Clinical Oncology 2010 [53]	SELDI-TOF	80 BC 40 HC	96.45%	94.87%	Yes N = 44 BC, 98 BBD, 20 HC
Belluco et al. Annals of Surgical Oncology 2007 [54]	SELDI-TOF	109 BC 109 HC	95.6%	86.5%	Yes N = 46 BC, 46 HC
Callesen et al. Journal of Proteome Research 2008 [55]	SELDI-TOF	48 BC 28 HC	85%	85%	No
Li et al. Clinical Chemistry 2002 [56]	SELDI-TOF	103 BC 25 BBD 41 HC	93%	91%	No
Vlahou et al. Clinical Breast Cancer 2003 [57]	SELDI-TOF	45 BC 42 BBD 47 HC	80%	79%	No
De Noo et al. Onkologie 2006 [45]	MALDI-TOF	78 BC 29 HC	100%	97%	No

BC = Breast cancer, BBD = Benign breast disease, HC = Healthy controls.