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. 2010 Nov 9;11(11):4465–4487. doi: 10.3390/ijms11114465

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© 2010 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Figure 2. — Number of apomorphine-induced contralateral rotations in rats (n = 8 per group). The number of apomorphine-induced contralateral rotations were documented over 30 min on days 14, 21 and 28 after a unilateral intrastriatal injection of 6-OHDA (20 μg) into the right striatum. Apomorphine was administered subcutaneously at a dose of 0.2 mg/kg. Pretreatment with saline (SAL, 1 mL/kg) or mildronate at a dose of 50 mg/kg (M50) was performed via intraperitoneal administration for two weeks before the administration of 6-OHDA (SAL + 6-OHDA and M50 + 6-OHDA), at ** p < 0.01, M50 + 6-OHDA vs. SAL + 6-OHDA group, day 21, unpaired t-test.