Table 4. Comparison of histopathologic features of preulcerative and ulcerative lesions in definite Buruli ulcer cases.
| Histopathologic feature | Preulcerative no. (%) | Ulcerative no. (%) | p value | |
|---|---|---|---|---|
|
Epidermis
|
8 (42) |
42 (78) |
0.005 |
|
| Hyperplasiaa |
|
|
|
|
|
Dermis
|
17 (85) |
28(52) |
0.015 |
|
| Elastolysisa |
|
|
|
|
| AFB in dermisb |
8 (40) |
10 (19) |
0.34 |
|
|
Subcutaneous tissue
|
|
|
|
|
| AFB in subcutisc |
18 (78) |
31 (56) |
0.074 |
|
| Acute inflammationd |
22 (96) |
50 (91) |
0.48 |
|
| Chronic inflammatione |
4 (17) |
27 (49) |
0.013 |
|
| Granulomasf | 3 (13) | 27 (49) | 0.005 |
aTwo specimens did not have epidermis, and one did not have dermis. bConsidered as presence of acid-fast bacili (AFB) in dermis. cConsidered as intense versus mild AFB in subcutis. dAcute inflammation considered as present versus absent. eChronic inflammation considered as intense versus mild. fGranulomas considered as present versus absent.