Table 2. Study population characteristics.
CFH Y402H | ARMS2 A69S | ||||||
---|---|---|---|---|---|---|---|
Genotype | All | CC | CT | TT | TT | GT | GG |
Genotype frequency | - | 28 (31.1%) | 47 (52.2%) | 15 (16.7%) | 26 (28.9%) | 33 (36.7%) | 31 (34.4%) |
Lesion area | 15.64 | 17.82 | 14.75 | 14.38 | 15.31 | 16.81 | 14.68 |
[mm2] | ±10.63 | ±13.22 | ±10.26 | ±7.16 | ±11.88 | ±10.0 | ±10.4 |
Kruskal–Wallis test H (2, n=90)=0.6011253 p=0.74 H (2, n=90)=1.366674 p=0.505 | |||||||
Type of CNV | 31:30 | 11:10:7 | 14:16:17 | 6:4:5 | 12:9:13 | 12:10:11 | 7:11:5 |
pdc:mc:oc | 29 | ||||||
Kruskal–Wallis test H (2, n=90)=0.6248223 p=0.732 H (2, n=90)=4.495667 p=0.106 | |||||||
BCVA | 41.79 | 40.28 | 43.51 | 39.2 | 41.31 | 38.79 | 45.39 |
[letters] | ±14.52 | ±15.62 | ±14.19 | ±13.66 | ±16.47 | ±13.7 | ±13.26 |
Kruskal–Wallis test H (2, n=90)=1.164551 p=0.559 H (2, n=90)=3.937457 p=0.14 | |||||||
BCVA after 12 months | 46.23 | 42.32 | 49.06 | 44.67 | 42.65 | 43.12 | 52.55 |
[letters] | ±16.54 | ±16.77 | ±15.78 | ±17.82 | ±17.09 | ±16.93 | ±14.13 |
(4.44±8.12) | (2.04±6.01) | (5.55 | (5.47 | (1.35 | (4.33 | (7.16 | |
±9.53) | ±5.85) | ±8.87) | ±8.92) | ±5.39) | |||
p<0.01 | p=0.04 | p<0.01 | p<0.01 | p=0.5 | p<0.01 | p<0.01 | |
CSRT [µm] | 331.95±99.05 | 333.71±85.53 | 332.85 | 325.87 | 312.85 | 338.18 | 341.35 |
±100.22 | ±123.31 | ±103.54 | ±89.69 | ±105.55 | |||
Kruskal–Wallis test H (2, n=90)=1.164551 p=0.559 H (2, n=90)=3.937457 p=0.14 | |||||||
CSRT after 12 months [µm] | 228.32 | 234.61 | 231.36 | 207.07 | 223.58 | 206.09 | 255.97 |
±72.27 | ±80.08 | ±71.59 | ±58.35 | ±82.03 | ±46.69 | ±78.80 | |
(103.63±94.7) | (99.11 | (101.49 | (118.8 | (89.27 | (132.09 | (85.39 ±91.98) | |
p<0.01 | ±83.49) | ±92.87) | ±122.19) | ±100.66) | ±88.16) | p<0.01 | |
p<0.01 | p<0.01 | p<0.01 | p<0.01 | p<0.01 | |||
Injections | 5.77±1.51 | 5.96±1.64 | 5.83±1.34 | 5.2±1.74 | 5.85±1.51 | 5.79±1.56 | 5.68±1.51 |
BCVA – best-corrected visual acuity, CNV – choroidal neovascularization (pdc-predominantly classic, mc-minimally classic, oc-occult), CSRT – central subfield retinal thickness