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. Author manuscript; available in PMC: 2011 Dec 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Nov 11;30(12):2350–2356. doi: 10.1161/ATVBAHA.110.207498

Figure 1. Structure and conformation of oxidized phospholipids specific ligands for CD36 (oxPCCD36).

Figure 1

Truncated oxidized fatty acid esterified to the sn-2 position of oxidized phosphatidylcholine (PC) is shown. It contains a terminal aldehyde or carboxylic acid, a double bond in the βposition, and a ketone or alcohol in the γposition. The core structural motif conserved amongst the various oxidized PC species that are high affinity ligands for CD36 is shown in red. b) Unusual conformation of oxPCCD36 in the phospholipid membrane. The truncated polar sn-2 fatty acid moiety of oxPCCD36 protrudes into the aqueous phase, rendering it accessible for the receptors such as class B scavenger receptors.