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. 2010 Dec 9;5(12):e14185. doi: 10.1371/journal.pone.0014185

Figure 5. Isolation-induced resident-intruder test.

Figure 5

NRG1-Tg5 mice (A, C, E) and Tg7 mice (B, D, F) and their WT littermates were subjected to a isolation-induced resident-intruder test. (A–D) Social scores of anogenital sniffing (An. sniff), non-anogenital sniffing (Non-an. sniff) and non-agonistic social behaviors (Non-ago. social) were measured over a 10-min period. The non-agonistic behaviors represent grooming and lying down next to each other of resident mice. (E, F) Aggressive behaviors, which represent aggressive following, attacks and threats, were counted in parallel. (A, B) Time spent by the resident males actively pursuing social behaviors. (C, D) The frequency of social behaviors in the resident males is shown. (E, F) The frequency of aggressive behaviors of the resident males was compared between the NRG1-Tg mice and their WT littermates (N = 11 for Tg5, N = 10 for WT; and N = 7 for Tg7, N = 7 for WT, all males). Data are expressed as mean±S.E.M. *P<0.05, **P<0.01, ***P<0.001 compared to WT littermates by unpaired two-tailed t-test.