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. 2010 Dec 9;5(12):e14185. doi: 10.1371/journal.pone.0014185

Figure 7. Analysis of dopamine metabolism and neurochemical markers for dopaminergic neurons of NRG1 transgenic mice.

Figure 7

Levels of dopamine and its metabolites (DOPAC and HVA) (A, B, C) as well as those of dopamine-related molecular markers (D, E, F) were measured in (A, D) frontal cortex, (B, E) striatum and (C, F) hippocampus of NRG1-Tg5 and WT mice at the adult stage. Typical immunoblots for TH, DBH, DAT, D1DR, D2DR, and vMAT2 were displayed. Each immunoreactivity was measured by densitometric analysis, normalized to β-actin levels and its ratio to that of WT littermates was displayed (N = 4–5 each, all males). Data are expressed as mean±S.E.M. (% of WT). *P<0.05, **P<0.01, ***P<0.001, compared to WT littermates by unpaired two-tailed t-test.