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. 2010 Dec 9;6(12):e1001237. doi: 10.1371/journal.pgen.1001237

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Liu, Lu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The flies of each indicated genotype were crossed to Mhc-Gal4>PINK1 RNAi flies (A) or Mhc-Gal4 flies (B), and the percentage of male offspring with abnormal wing posture phenotype was scored at 1-day and 14-day after eclosion. The flies were aged at 29°C. Data are presented as mean ± s.e.m. The genetic interactions between PINK1 and genes of the TOR pathway, autophagy pathway, mitochondrial fusion and fission machinery or antioxidant genes are demonstrated. The differences in abnormal wing posture phenotype between the genetic interaction flies and control flies shown in (A) are all statistically significant (P<0.005 in Student's t-test).