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. Author manuscript; available in PMC: 2012 Feb 29.
Published in final edited form as: FEBS J. 2010 Aug 31;277(19):3864–3875. doi: 10.1111/j.1742-4658.2010.07797.x

Fig. 1.

Fig. 1

Schematic representation of decorin effects as an antiproliferative (left panel) and proliferative (right panel) molecule. In most cancer cells so far investigated, decorin causes a downregulation of EGFR and Met with consequent activation of p21 and caspase-3, which leads to apoptosis. Decorin also interferes with the non-canonical β-catenin pathway via the Met receptor. In normal cells such renal tubular epithelial cells, decorin evokes a pro-survival and proliferative response via the IGF-IR and downstream signaling. Please, refer to the text for additional information.