Table 3.

VBM Results (Note: Only peaks are reported here. See text for details.)

Region	BA	Talairach Coordinates			T	P (corr)	Cluster
		x	y	z
GRAY MATTER VOLUME
Main Effect of Group: Control > 22q11.2DS
Left Lingual, Posterior Cingulate Gyri, Cuneus	7, 18, 30	0	-72	-1	8.75	<0.001	62954
		-7	-58	6	8.37
		-10	-66	30	6.69
Main Effect of Group: 22q11.2DS > Control
Left Inferior, Medial Frontal Gyri, Right Caudate Head	47, 11	-18	34	-13	7.96	<0.001	216349
		-8	46	-12	7.41
		8	2	0	7.13
Main Effect of Time: Time 1 > Time 2
Right Middle Temporal, Middle Occipital Gyri, Left Superior Temporal Gyrus	37, 39	32	-58	24	15.45	<0.001	1173427
		37	-61	9	14.72
		-32	-57	29	13.82
Main Effect of Time: Time 2 > Time 1
n.s.
Interaction
n.s
22q11.2DS: Correlation between Decrease in GMV and Higher 2 BPRS Scores
Left Middle, Medial Frontal Gyri	8, 9	-25	25	43	4.76	<0.001	28552
		-10	32	32	4.68
		-9	28	47	4.59
WHITE MATTER VOLUME
Main Effect of Group: Control > 22q11.2DS
Left Cerebellar Region		15	-40	-35	7.68	0.005	12797
		-34	-63	-29	6.59
		-3	-39	-16	5.96
Left Occipital, Parietel Regions		-4	-81	1	7.49	<0.001	23725
		-9	-74	-2	6.59
		-19	-83	18	5.55
Main Effect of Group: 22q11.2DS > Control
Bilateral Medial Frontal, Left Parietal Regions		-9	23	-10	7.7	<0.001	125706
		9	29	-4	7.48
		46	-46	46	6.82
Main Effect of Time: Time 1 > Time 2
n.s.
Main Effect of Time: Time 2 > Time 1
Left Brainstem, Right Medial Frontal Region		-10	-19	-5	12.67	<0.001	659495
		-12	-10	-7	12.54
		13	2	-2	12.14
Interaction: [22q11.2DS > Controls] × [Time 2 > Time 1]
Left Lateral Frontal, Right Medial Frontal Regions		-40	16	13	4.65	<0.001	166654
		10	-34	7	4.6
		12	4	37	4.56
Interaction: [Controls > 22q11.2DS] × [Time 2 > Time 1]
n.s.