Figure 6.

Comparison of architecture in symptomatic and asymptomatic legs. (A) Lower legs of a 23-year-old woman (subject LL05) with lymphedema on the left leg (right in images). Asymptomatic limb looks normal, although it has a paucity of lymphatic vessels, whereas the symptomatic limb has diffuse extravascular fluorescence with no distinct structure. (B) A closer look at the ankles of the same subject as (A) shows that the asymptomatic limb has a tortuous vessel emanating from the injections site, whereas the symptomatic limb shows diffuse extravascular fluorescence again with perhaps a large curved lymphatic vessel just above the ankle bone. (C) Image illustrating the diffusion of dye into the symptomatic foot of the same subject. (D) Lower legs of a 65-year-old woman (subject LL10) with clinically diagnosed lymphedema on the right leg (left in image). Both symptomatic and asymptomatic legs show extensive diffuse extravascular fluorescence, although some structure is apparent in asymptomatic limb.