Figure 5.
Time history of the force experienced by a microvillus (left y axis, black lines) and probability of being attached to the substrate (right y axis, red lines) as it moves past the trailing edge during cell rolling. Cells with different cortical tensions of 10 pN/μm (a) and 100 pN/μm (b) are shown side by side for two different shear stresses. Snapshots of cell rolling under these conditions are depicted to scale, with microvillus densities proportional to the density obtained from the model. Rolling velocity (Vx) and total number of extended microvilli (NMV) at a given instant are also specified.