Figure 1.

Tooth formation in vitro from combinations of mouse epithelial and mesenchymal cells. The epithelium (red arrow) and mesenchyme (black arrow) are separated from pre-bud stage tooth primordia,and cells dissociated in single cell populations. (a) The cells are recombined (as shown in this figure) and grown in vitro for 6 days. (b) Gross appearance after 9 days in culture with higher magnification of a tooth primordium. (c) Sections of tooth primordia from (a), showing development to the bell stage.