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. Author manuscript; available in PMC: 2012 Jan 12.
Published in final edited form as: Tetrahedron Lett. 2011 Jan 12;52(2):219–223. doi: 10.1016/j.tetlet.2010.10.173

Table 3.

Concentration of iminosugars giving 50% inhibition of various glycosidases and glycogen phosphorylase.

IC50 (μM)
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Enzyme DAB 3D isoDAB 2D 4-C-Me-DAB 1D LAB 3L isoLAB 2L 4-C-Me-LAB 1L
α-Glucosidase
 Rice 250 41 7.1 3.2 NI 5.8
 Yeast 0.15 NI 1.9 70 NI NI
 Rat intestinal maltase 55 24 0.74 0.93 NI 2.4
 Rat intestinal isomaltase 5.8 20 3.4 0.36 NI 5.1
 Rat intestinal sucrase 16 15 0.41 1.0 NI 0.66
β-Glucosidase
 Almond 250 NI NI NI NI NI
 Bovine liver 638 NI NI NI NI NI
 Rat intestinal cellobiase 756 NI NI NI NI NI
α-Galactosidase
 Coffee beans NIa NI NI NI NI NI
 Human lysosome NI NI NI NI NI NI
β-Galactosidase
 Bovine liver NI NI NI NI NI NI
 Rat intestinal lactase 323 NI NI 415 NI NI
α-Mannosidase
 Jack beans 320 NI NI NI NI NI
β-Mannosidase
 Snail NI NI NI NI NI NI
α-l-Rhamnosidase
 P. decumbens NI NI NI NI NI NI
α-l-Fucosidase
 Bovine epididymis NI NI NI NI NI NI
Trehalase
 Rat intestinal trehalase 61 NI 38 75 NI NI
Glycogen phosphorylase
 Rabbit muscle 0.33 NI NI NI NI NI
a

NI: No inhibition (less than 50% inhibition at 1000 μM).