Figure 5.

α₁ Receptors produce a decrease in LI-eIPSCs amplitude. Averaged time course of the effect of adrenergic agonists and antagonists on eIPSCs. (A) Temporal course showing that the α₁ adrenoceptor blocker prazosin (1 μM) blocks the effects of NE. (B) The antagonists for β and α₂ receptors (propranolol and yohimbine, 1 μM) did not block the NE action on LI-eIPSCs, suggesting that α₁ receptors activation modulated LI-eIPSCs. (C) Phenylephrine (1 μM) decreases LI-eIPSCs amplitude. (D) Previous application of prazosin blocked LI-eIPSCs reduction by the selective α₁ noradrenergic receptor (phenylephrine 1 μM). (E) Summary of results with agonists and antagonists indicating that α₁ receptors are responsible for NE-induced reduction in LI-eIPSCs amplitude.