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. 2010 May 13;21(1):212–221. doi: 10.1093/cercor/bhq081

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© The Author 2010. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com

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Figure 7. — α₁ - PLC is responsible for NE-induced modulation of LI-eIPSCs. NE effects after slice preincubation with the PLC blocker U73122 (10 μM) for >3 h. (A) Time course showing that U73122 preincubation blocks all effects of NE on LI-eIPSCs. (B) Bar graph summarizing NE effects. Mean ± standard error of the mean of NE-induced depression of LI-eIPSCs. (C) Time course of NE effects on LII/III-eIPSCs after preincubation in U73122. PLC blockage does not prevent the modulation of NE in LII/III. (D) Bar graph summarizing the effects of NE. Mean ± standard error of NE-induced enhancement on eIPSCs. These data suggest that α₁ receptors are associated with PLC pathway.